Title : Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation.

Pub. Date : 2011 Dec

PMID : 22019228






1 Functional Relationships(s)
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1 Among them, compound 8d, (o-methylphenethyl)amino linked at the 9-position of berberine, was found to be a good antioxidant (with 4.05 muM of Trolox equivalents), potent inhibitor of AChE (an IC(50) value of 0.027 muM), and high active inhibitor of amyloid-beta aggregation (an IC(50) value of 2.73 muM). Berberine acetylcholinesterase (Cartwright blood group) Homo sapiens