Title : Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9.

Pub. Date : 2012 Feb

PMID : 22011645






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1 Our results show that a novel, double tyrosine mutant of AAV9 significantly enhanced gene delivery to the CNS and retina, and that gene expression can be restricted to rod photoreceptor cells by incorporating a rhodopsin promoter. Tyrosine rhodopsin Homo sapiens