Title : Parthenolide attenuates LPS-induced fever, circulating cytokines and markers of brain inflammation in rats.

Pub. Date : 2011 Dec

PMID : 22004922






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1 In summary, pretreatment with parthenolide attenuates the febrile response during LPS-induced systemic inflammation by reducing circulating IL-6 and TNFalpha and decreasing hypothalamic NFkappaB/NF-IL6 activation, oxidative stress and expression of COX2. parthenolide CCAAT/enhancer binding protein beta Rattus norvegicus