Pub. Date : 2011
PMID : 22003289
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suppression of IL-8 production from airway cells by tiotropium bromide in vitro. | Tiotropium Bromide | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | PURPOSE: The present study aimed to examine the influence of tiotropium bromide on the production of interleukin (IL)-8 from human airway epithelial cells and lung fibroblasts (LFs) after lipopolysaccharide (LPS) stimulation in vitro. | Tiotropium Bromide | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | RESULTS: Tiotropium bromide at > 15 pg/mL inhibited IL-8 production from both BEAS-2B cells and LFs after LPS stimulation. | Tiotropium Bromide | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | Tiotropium bromide also suppressed IL-8 mRNA expression through the inhibition of NF-kappaB activation and signaling protein, extracellular-signal-regulated kinase 1/2, and c-Jun N-terminal kinase, phosphorylation. | Tiotropium Bromide | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 5 | CONCLUSION: The present results strongly suggest that tiotropium bromide exerts the inhibitory effect on neutrophilic inflammation through the suppression of IL-8 production from epithelial cells and LFs by interfering with LPS-mediated signaling pathways and thus may contribute to lower cellular inflammation in COPD, which is responsible for favorable modification of the disease. | Tiotropium Bromide | C-X-C motif chemokine ligand 8 | Homo sapiens |