Title : A novel preclinical strategy for identifying cardiotoxic kinase inhibitors and mechanisms of cardiotoxicity.

Pub. Date : 2011 Dec 9

PMID : 21998323






1 Functional Relationships(s)
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1 Sorafenib is a KI of concern because it inhibits growth factor receptors and Raf-1/B-Raf, kinases that are upstream of extracellular signal-regulated kinases (ERKs) and signal cardiomyocyte survival in the setting of stress. Sorafenib Raf-1 proto-oncogene, serine/threonine kinase a Danio rerio