Title : Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production.

Pub. Date : 2011 Dec

PMID : 21993412






5 Functional Relationships(s)
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1 In this study, p-cresol (1-5 muM) inhibited the arachidonic acid (AA)-induced platelet aggregation, with 47% and 82% of inhibition at concentrations of 2 and 5 muM, respectively. 4-cresol latexin Homo sapiens
2 In this study, p-cresol (1-5 muM) inhibited the arachidonic acid (AA)-induced platelet aggregation, with 47% and 82% of inhibition at concentrations of 2 and 5 muM, respectively. 4-cresol latexin Homo sapiens
3 P-cresol (2-100 muM) partly inhibited the AA-induced reactive oxygen species (ROS) production as well as the extracellular signal-regulated kinase (ERK1/2) and p38 phosphorylation in platelets. 4-cresol latexin Homo sapiens
4 P-cresol further inhibited the AA-induced aggregation of rabbit platelet-rich plasma (PRP) with an IC50 of 2 muM and aggregation of human PRP (IC50 = 13.6 muM). 4-cresol latexin Homo sapiens
5 P-cresol further inhibited the AA-induced aggregation of rabbit platelet-rich plasma (PRP) with an IC50 of 2 muM and aggregation of human PRP (IC50 = 13.6 muM). 4-cresol latexin Homo sapiens