Title : Sorafenib-induced apoptosis of chronic lymphocytic leukemia cells is associated with downregulation of RAF and myeloid cell leukemia sequence 1 (Mcl-1).

Pub. Date : 2012 Feb 10

PMID : 21979753






2 Functional Relationships(s)
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1 One single dose of 10 mumol/L or the repeated addition of 1 mumol/L sorafenib caused caspase-dependent apoptosis and reduced levels of phosphorylated B-RAF, C-RAF, extracellular signal-regulated kinase (ERK), signal transducer and activator of transcription 3 (STAT3) and myeloid cell leukemia sequence 1 (Mcl-1) in CLL cells in the presence of the microenvironment. Sorafenib signal transducer and activator of transcription 3 Homo sapiens
2 One single dose of 10 mumol/L or the repeated addition of 1 mumol/L sorafenib caused caspase-dependent apoptosis and reduced levels of phosphorylated B-RAF, C-RAF, extracellular signal-regulated kinase (ERK), signal transducer and activator of transcription 3 (STAT3) and myeloid cell leukemia sequence 1 (Mcl-1) in CLL cells in the presence of the microenvironment. Sorafenib signal transducer and activator of transcription 3 Homo sapiens