Pub. Date : 2011 Dec
PMID : 21971158
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The antidiabetic drug, metformin, is known to increase circulating GLP-1 levels, although its mechanism of action is unknown. | Metformin | glucagon like peptide 1 receptor | Homo sapiens |
| 2 | Treatment of rats with metformin (300 mg/kg, per os) or aminoimidazole carboxamide ribonucleotide (250 mg/kg, sc) increased plasma total GLP-1 over 2 h, reaching 37 +- 9 and 29 +- 9 pg/ml (P < 0.001), respectively, compared with basal (7 +- 1 pg/ml). | Metformin | glucagon like peptide 1 receptor | Homo sapiens |
| 3 | Pretreatment with the nonspecific muscarinic antagonist, atropine (1 mg/kg, iv), decreased metformin-induced GLP-1 secretion by 55 +- 11% (P < 0.05). | Metformin | glucagon like peptide 1 receptor | Homo sapiens |
| 4 | In contrast, pretreatment with the gastrin-releasing peptide antagonist, RC-3095 (100 mug/kg, sc), reduced the GLP-1 response to metformin, by 55 +- 6% (P < 0.01) at 30 min. | Metformin | glucagon like peptide 1 receptor | Homo sapiens |
| 5 | These studies elucidate the mechanism underlying metformin-induced GLP-1 secretion and highlight the benefits of using metformin with dipeptidylpeptidase-IV inhibitors in patients with type 2 diabetes. | Metformin | glucagon like peptide 1 receptor | Homo sapiens |