Pub. Date : 2011 Nov 15
PMID : 21964418
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although all of the oxidation reactions tested were more or less inhibited by PFOS, diclofenac 4"-hydroxylation mediated mainly by CYP2C9 was most strongly inhibited (K(i) value of 40 nM), followed by paclitaxel 6alpha-hydroxylation mediated mainly by CYP2C8 (K(i) value of 4 muM). | perfluorooctane sulfonic acid | latexin | Homo sapiens |
| 2 | The substrate oxidation reactions catalyzed by CYP2A6, CYP2B6, CYP2C19 and CYP3A4 were moderately (K(i) values of 35 to 45 muM), and those by CYP1A2, CYP2D6 and CYP2E1 were weakly inhibited by PFOS (K(i) values of 190-300 muM). | perfluorooctane sulfonic acid | latexin | Homo sapiens |