Pub. Date : 2011
PMID : 21961053
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CDDO-Me inhibited the growth of murine TRAMPC-1 prostate cancer cells by inducing apoptosis through the inhibition of antiapoptotic p-Akt, p-mTOR and NF-kappaB. | bardoxolone methyl | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | Treatment with CDDO-Me inhibited the expression of prosurvival p-Akt and NF-kappaB in the prostate and knocking-down Akt in TRAMPC-1 tumor cells sensitized them to CDDO-Me. | bardoxolone methyl | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | Treatment with CDDO-Me inhibited the expression of prosurvival p-Akt and NF-kappaB in the prostate and knocking-down Akt in TRAMPC-1 tumor cells sensitized them to CDDO-Me. | bardoxolone methyl | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | These findings indicated that Akt is a target for apoptoxicity in TRAMPC-1 cells in vitro and potentially a target of CDDO-Me for inhibition of prostate cancer in vivo. | bardoxolone methyl | thymoma viral proto-oncogene 1 | Mus musculus |