Title : Natural variations at position 93 of the invariant Vα24-Jα18 α chain of human iNKT-cell TCRs strongly impact on CD1d binding.

Pub. Date : 2012 Jan

PMID : 21956730






1 Functional Relationships(s)
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1 By generating recombinant refolded iNKT-cell TCRs, we show that natural single-nucleotide variations in iNKTalpha, translating to serine, threonine, asparagine or isoleucine at p93, exert a powerful effect on CD1d binding, with up to 28-fold differences in affinity between these variants. Asparagine CD1d molecule Homo sapiens