Pub. Date : 2012 Apr
PMID : 21951103
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Melatonin suppresses acrolein-induced IL-8 production in human pulmonary fibroblasts. | Melatonin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | In this study, we investigated whether melatonin suppresses acrolein-induced IL-8 secretion in human pulmonary fibroblasts (HPFs). | Melatonin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | It was found that acrolein-induced IL-8 production was accompanied by increased levels of phosphorylation of Akt and extracellular signal-regulated kinases (ERK1/2) in HPFs, and that melatonin suppressed IL-8 production in HPFs. | Melatonin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | These results suggest that melatonin suppresses acrolein-induced IL-8 production via ERK1/2 and phosphatidylinositol 3-kinase (PI3K)/Akt signal inhibition in HPFs. | Melatonin | C-X-C motif chemokine ligand 8 | Homo sapiens |