Title : The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease.

Pub. Date : 2011 Dec

PMID : 21951066






2 Functional Relationships(s)
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Protein Name
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1 We specifically show that inhibition of ERbeta mediates 27-OHC-induced decrease in TH expression, an effect reversed by the ER agonist estradiol. 27-hydroxycholesterol estrogen receptor 1 Homo sapiens
2 Concomitant activation of ERbeta and inhibition of LXRbeta prevent 27-OHC effects and may therefore reduce the progression of Parkinson"s disease by precluding TH reduction and alpha-synuclein accumulation. 27-hydroxycholesterol estrogen receptor 1 Homo sapiens