Title : Microcystin-LR acute exposure increases AChE activity via transcriptional ache activation in zebrafish (Danio rerio) brain.

Pub. Date : 2012 Mar

PMID : 21946396






5 Functional Relationships(s)
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1 In vivo studies showed that 100 mug/L MC-LR led to a significant increase in the AChE activity (27%) when zebrafish were exposed to the toxin dissolved in water, but did not cause any significant changes when injected intraperitoneally. cyanoginosin LR acetylcholinesterase Danio rerio
2 In addition, semiquantitative RT-PCR analysis demonstrated that 100 mug/L MC-LR exposure also increased ache mRNA levels in zebrafish brain. cyanoginosin LR acetylcholinesterase Danio rerio
3 These findings provide the first evidence that brain AChE is another potential target for MCs and suggest that the observed increases in AChE enzymatic activity and in ache transcript levels after MC-LR exposure depend, at least partially, on branchial uptake or ingestion. cyanoginosin LR acetylcholinesterase Danio rerio
4 These findings provide the first evidence that brain AChE is another potential target for MCs and suggest that the observed increases in AChE enzymatic activity and in ache transcript levels after MC-LR exposure depend, at least partially, on branchial uptake or ingestion. cyanoginosin LR acetylcholinesterase Danio rerio
5 These findings provide the first evidence that brain AChE is another potential target for MCs and suggest that the observed increases in AChE enzymatic activity and in ache transcript levels after MC-LR exposure depend, at least partially, on branchial uptake or ingestion. cyanoginosin LR acetylcholinesterase Danio rerio