Title : Modulation of the expression of ABC transporters in murine (J774) macrophages exposed to large concentrations of the fluoroquinolone antibiotic moxifloxacin.

Pub. Date : 2011 Dec 18

PMID : 21946100






1 Functional Relationships(s)
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1 We previously showed that mouse J774 macrophages cultivated for a prolonged period of time with toxic concentrations of the fluoroquinolone ciprofloxacin overexpress the efflux transporter Mrp4 and display a reduced accumulation of this antibiotic, but no change in the accumulation of moxifloxacin, a closely related molecule (Antimicrob. Ciprofloxacin ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Mus musculus