Title : An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.

Pub. Date : 2011 Nov

PMID : 21937706






1 Functional Relationships(s)
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1 The cytoplasmic THOC5-dependent mRNAs were recovered by treatment with ATM kinase-specific or p53-specific siRNA, as well as by treatment with ATM kinase inhibitor, KU55933, under DNA damage conditions, suggesting that the ATM-kinase-p53 pathway is involved in this response to the DNA damage. 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one tumor protein p53 Homo sapiens