Pub. Date : 2012 Apr 26
PMID : 21927021
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation. | Cisplatin | checkpoint kinase 1 | Homo sapiens |
| 2 | A determinant of CDDP sensitivity in OVCA, p53, is activated by checkpoint kinase 1 (Chk1) in response to DNA damage. | Cisplatin | checkpoint kinase 1 | Homo sapiens |
| 3 | A determinant of CDDP sensitivity in OVCA, p53, is activated by checkpoint kinase 1 (Chk1) in response to DNA damage. | Cisplatin | checkpoint kinase 1 | Homo sapiens |
| 4 | Our findings establish for the first time that PPM1D confers CDDP resistance in OVCA cells through attenuating CDDP-induced, Chk1-mediated, p53-dependent apoptosis. | Cisplatin | checkpoint kinase 1 | Homo sapiens |
| 5 | Our findings establish for the first time that PPM1D confers CDDP resistance in OVCA cells through attenuating CDDP-induced, Chk1-mediated, p53-dependent apoptosis. | Cisplatin | checkpoint kinase 1 | Homo sapiens |