Pub. Date : 2011 Dec
PMID : 21925266
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Isradipine is a Federal Drug Administration-approved dihydropyridine calcium channel blocker that binds selectively to Ca(v)1.2 in the hippocampus. | Isradipine | immunoglobulin lambda variable 2-8 | Homo sapiens |
| 2 | Our studies have shown that isradipine in vitro attenuates beta amyloid oligomer toxicity by suppressing calcium influx into cytoplasm and by suppressing Ca(v)1.2 expression. | Isradipine | immunoglobulin lambda variable 2-8 | Homo sapiens |
| 3 | This review highlights the importance of Ca(v)1.2 channel overexpression, the accumulation of hyperphosphorylated tau and suppression of autophagy in Alzheimer"s disease and modulation of this pathway by isradipine. | Isradipine | immunoglobulin lambda variable 2-8 | Homo sapiens |