Title : CITED2 controls the hypoxic signaling by snatching p300 from the two distinct activation domains of HIF-1α.

Pub. Date : 2011 Dec

PMID : 21925214






3 Functional Relationships(s)
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1 We also found that pVHL inhibits NAD activity regardless of NAD degradation by blocking the interaction between p300 and NAD. nadide von Hippel-Lindau tumor suppressor Homo sapiens
2 Summarizing, NAD was activated by binding to p300, and this was blocked by either CITED2 or pVHL. nadide von Hippel-Lindau tumor suppressor Homo sapiens
3 We propose that pVHL controls NAD during normoxia and that CITED2 controls NAD during hypoxia. nadide von Hippel-Lindau tumor suppressor Homo sapiens