Pub. Date : 2011 Dec
PMID : 21925214
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, few researches have focused on the role of CITED2 in the regulation of NAD activity, and thus, we addressed this point. | nadide | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | Homo sapiens |
| 2 | CITED2 was found to attenuate the hypoxic activations of NAD-dependent and CAD-dependent genes, suggesting that CITED2 negatively regulates both CAD and NAD. | nadide | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | Homo sapiens |
| 3 | CITED2 was found to attenuate the hypoxic activations of NAD-dependent and CAD-dependent genes, suggesting that CITED2 negatively regulates both CAD and NAD. | nadide | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | Homo sapiens |
| 4 | CITED2 was found to attenuate the hypoxic activations of NAD-dependent and CAD-dependent genes, suggesting that CITED2 negatively regulates both CAD and NAD. | nadide | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | Homo sapiens |
| 5 | CITED2 was found to attenuate the hypoxic activations of NAD-dependent and CAD-dependent genes, suggesting that CITED2 negatively regulates both CAD and NAD. | nadide | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | Homo sapiens |
| 6 | Furthermore, CITED2 was found to inactivate NAD by interfering with NAD binding to CH1, but not to CH3. | nadide | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | Homo sapiens |
| 7 | Furthermore, CITED2 was found to inactivate NAD by interfering with NAD binding to CH1, but not to CH3. | nadide | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | Homo sapiens |
| 8 | These results indicate that CITED2 inactivates HIF-1alpha by blocking p300 recruitment by both NAD and CAD. | nadide | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | Homo sapiens |
| 9 | Summarizing, NAD was activated by binding to p300, and this was blocked by either CITED2 or pVHL. | nadide | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | Homo sapiens |
| 10 | We propose that pVHL controls NAD during normoxia and that CITED2 controls NAD during hypoxia. | nadide | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | Homo sapiens |