Title : [Tumor necrosis factor-α promote permeability of human umbilical vein endothelial cells via activating RhoA-ERK1/2 pathway].

Pub. Date : 2011 Jun

PMID : 21924080






1 Functional Relationships(s)
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1 To explore the signaling pathways behind TNF-alpha-induced changes in HUVEC morphology and permeability, HUVECs were treated with either the Rho GTPase inhibitor Y27632 or the mitogen-activated protein kinases (MAPK) inhibitors PD98059 and SB203580 before TNF-alpha administration. SB 203580 tumor necrosis factor Homo sapiens