Pub. Date : 2011
PMID : 21909411
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |
| 2 | The goal of the present study was to achieve more understanding on the modification/s of carnitinepalmitoyltransferase-I (CPT-I), the rate-limiting enzyme of the mitochondrial fatty acid beta-oxidation, during steatohepatitis. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |
| 3 | The goal of the present study was to achieve more understanding on the modification/s of carnitinepalmitoyltransferase-I (CPT-I), the rate-limiting enzyme of the mitochondrial fatty acid beta-oxidation, during steatohepatitis. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |
| 4 | A high fat/methionine-choline deficient (MCD) diet, administered for 4 weeks, was used to induce NASH in rats.We demonstrated that CPT-I activity decreased, to the same extent, both in isolated liver mitochondria and in digitonin-permeabilized hepatocytes from MCD-diet fed rats.At the same time, the rate of total fatty acid oxidation to CO(2) and ketone bodies, measured in isolated hepatocytes, was significantly lowered in treated animals when compared to controls. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |