Pub. Date : 2012 Jan
PMID : 21898109
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genistein, a crucial non-nutrient component in soybean, exhibits anti-cancer effects by inhibiting protein tyrosine kinase that is involved in up-regulation of VEGF. | Genistein | vascular endothelial growth factor A | Homo sapiens |
| 2 | We further explored the role of genistein on countering the ATRA-induced VEGF expression. | Genistein | vascular endothelial growth factor A | Homo sapiens |
| 3 | Finally, expression of VEGF (both mRNA and protein) was diminished in A549 cells exposed to both ATRA and genistein. | Genistein | vascular endothelial growth factor A | Homo sapiens |
| 4 | In conclusion, our results demonstrate that genistein effectively enhances anti-cancer effects of ATRA, particularly, by countering the ATRA-induced up-regulation of VEGF. | Genistein | vascular endothelial growth factor A | Homo sapiens |