Title : A dual mechanism for I(Ks) current reduction by the pathogenic mutation KCNQ1-S277L.

Pub. Date : 2011 Dec

PMID : 21895724






1 Functional Relationships(s)
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1 BACKGROUND: The hereditary long QT syndrome is characterized by prolonged ventricular repolarization that can be caused by mutations to the KCNQ1 gene, which encodes the alpha subunits of the cardiac potassium channel complex that carries the I(Ks) current (the beta subunits are encoded by KCNE1). Potassium potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens