Title : The significance of early alpha-fetoprotein level changes in predicting clinical and survival benefits in advanced hepatocellular carcinoma patients receiving sorafenib.

Pub. Date : 2011

PMID : 21885876






4 Functional Relationships(s)
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1 The significance of early alpha-fetoprotein level changes in predicting clinical and survival benefits in advanced hepatocellular carcinoma patients receiving sorafenib. Sorafenib alpha fetoprotein Homo sapiens
2 AFP response was defined as a relative drop of AFP >20% of the baseline level after 6 weeks of sorafenib. Sorafenib alpha fetoprotein Homo sapiens
3 The relationship between AFP response and the treatment outcomes was first explored in patients who received sorafenib in a phase II study. Sorafenib alpha fetoprotein Homo sapiens
4 CONCLUSION: Drop in AFP level at 6 weeks is an exploratory early surrogate for both CB and PFS in advanced HCC patients receiving sorafenib. Sorafenib alpha fetoprotein Homo sapiens