Title : Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension.

Pub. Date : 2011 Nov

PMID : 21873498






2 Functional Relationships(s)
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1 Treatment of aortic rings with 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ; a blocker of guanylate cyclase) enhanced Phe contraction in LSD1(+/-) compared with WT mice on the HS diet. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one lysine (K)-specific demethylase 1A Mus musculus
2 Treatment of aortic rings with 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ; a blocker of guanylate cyclase) enhanced Phe contraction in LSD1(+/-) compared with WT mice on the HS diet. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one lysine (K)-specific demethylase 1A Mus musculus