Title : The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophages.

Pub. Date : 2011 Nov

PMID : 21868635






1 Functional Relationships(s)
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1 The results suggest that bisacodyl may decrease the expression of AQP3 in the colon, which inhibits water transfer from the luminal to the vascular side and leads to a laxative effect. Water aquaporin 3 (Gill blood group) Homo sapiens