Title : The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophages.

Pub. Date : 2011 Nov

PMID : 21868635






2 Functional Relationships(s)
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1 Thirty minutes after PGE(2) addition to HT-29 cells, the AQP3 expression level decreased to 40% of the control. Prostaglandins E aquaporin 3 (Gill blood group) Homo sapiens
2 This study also showed that direct activation of colon macrophages by bisacodyl increases the secretion of PGE(2), which acts as a paracrine factor and decreases AQP3 expression in colon mucosal epithelial cells. Prostaglandins E aquaporin 3 (Gill blood group) Homo sapiens