Title : Characterization of new potential anticancer drugs designed to overcome glutathione transferase mediated resistance.

Pub. Date : 2011 Oct 3

PMID : 21851097






1 Functional Relationships(s)
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1 Here we synthesized two derivatives of DOX, 2,4-dinitrobenzenesulfonyl doxorubicin (DNS-DOX) and 4-mononitrobenzenesulfonyl doxorubicin (MNS-DOX) and showed that they are substrates for MGST1 and GSTP (releasing DOX). dns-dox microsomal glutathione S-transferase 1 Homo sapiens