Pub. Date : 2011 Sep 30
PMID : 21846720
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The human candidate protein ACSF3, which has a predicted N-terminal mitochondrial targeting sequence, was cloned, expressed, and characterized as a 65-kDa acyl-CoA synthetase with extremely high specificity for malonate and methylmalonate. | malonic acid | acyl-CoA synthetase family member 3 | Homo sapiens |
| 2 | An arginine residue implicated in malonate binding by prokaryotic malonyl-CoA synthetases was found to be positionally conserved in animal ACSF3 enzymes and essential for activity. | malonic acid | acyl-CoA synthetase family member 3 | Homo sapiens |
| 3 | In conclusion, unlike fungi, which have an intramitochondrial acetyl-CoA carboxylase, animals require an alternative source of mitochondrial malonyl-CoA; the mitochondrial ACSF3 enzyme is capable of filling this role by utilizing free malonic acid as substrate. | malonic acid | acyl-CoA synthetase family member 3 | Homo sapiens |