Pub. Date : 2011 Nov 1
PMID : 21843532
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genistein, isoflavonoids in soybeans, prevents the formation of excess radiation-induced centrosomes via p21 up-regulation. | Genistein | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 2 | This suggests the inhibitory effect of genistein on the induction of extra centrosomes occurs through the inactivation of CDK2/Cyclin-A/E via p21 up-regulation. | Genistein | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 3 | This hypothesis is supported by the observation that p21 knockdown with siRNA reduced the activity of CDK2/Cyclin-A/E and restored the enhanced effect of a combined treatment with genistein and IR. | Genistein | cyclin dependent kinase inhibitor 1A | Homo sapiens |