Title : Involvement of human natural killer-1 (HNK-1) sulfotransferase in the biosynthesis of the GlcUA(3-O-sulfate)-Gal-Gal-Xyl tetrasaccharide found in α-thrombomodulin from human urine.

Pub. Date : 2011 Sep 23

PMID : 21828042






2 Functional Relationships(s)
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1 Because the human natural killer-1 sulfotransferase (HNK-1ST) transfers a sulfate group from 3"-phosphoadenosine 5"-phosphosulfate to the C-3 position of the nonreducing terminal GlcUA residue in the HNK-1 antigen precursor trisaccharide, GlcUAbeta1-3Galbeta1-4GlcNAc, the sulfotransferase activity toward the linkage region was investigated. Phosphoadenosine Phosphosulfate carbohydrate sulfotransferase 10 Homo sapiens
2 Furthermore, HNK-1ST also transferred a sulfate group from 3"-phosphoadenosine 5"-phosphosulfate to the C-3 position of the nonreducing terminal GlcUA residue of a chondroitin chain. Phosphoadenosine Phosphosulfate carbohydrate sulfotransferase 10 Homo sapiens