Title : Roles of heterotrimeric GTP-binding proteins in the progression of heart failure.

Pub. Date : 2011

PMID : 21821969






2 Functional Relationships(s)
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1 Using specific pharmacological tools to assess the involvement of G protein signaling pathways, we have revealed that alpha subunit of G(q) (Galpha(q)) activates Ca(2+)-dependent hypertrophic signaling through diacylglycerol-activated transient receptor potential canonical (TRPC) channels (TRPC3 and TRPC6: TRPC3/6). Diglycerides transient receptor potential cation channel subfamily C member 3 Homo sapiens
2 Using specific pharmacological tools to assess the involvement of G protein signaling pathways, we have revealed that alpha subunit of G(q) (Galpha(q)) activates Ca(2+)-dependent hypertrophic signaling through diacylglycerol-activated transient receptor potential canonical (TRPC) channels (TRPC3 and TRPC6: TRPC3/6). Diglycerides transient receptor potential cation channel subfamily C member 3 Homo sapiens