Title : Partially purified components of Nardostachys chinensis suppress melanin synthesis through ERK and Akt signaling pathway with cAMP down-regulation in B16F10 cells.

Pub. Date : 2011 Oct 11

PMID : 21816215






1 Functional Relationships(s)
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1 The specific MEK/ERK inhibitor PD98059 and PI3K/Akt inhibitor LY294002, block the PPNC-induced hypopigmentation effect, and abrogate the PPNC-suppressed expression of melanogenic proteins such as MITF, tyrosinase, TRP-1, and Dct. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one midkine Mus musculus