Title : The miRNA pathway limits AGO1 availability during siRNA-mediated PTGS defense against exogenous RNA.

Pub. Date : 2011 Nov

PMID : 21813456






3 Functional Relationships(s)
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1 Moreover, increasing AGO1 levels either by mutating miRNA pathway components or, more specifically, by impairing miR168-directed regulation of AGO1 mRNA leads to increased PTGS efficiency, indicating that the miRNA pathway dampens the efficiency of PTGS, likely by limiting the availability of AGO1. mir168 argonaute RISC component 1 Homo sapiens
2 Moreover, increasing AGO1 levels either by mutating miRNA pathway components or, more specifically, by impairing miR168-directed regulation of AGO1 mRNA leads to increased PTGS efficiency, indicating that the miRNA pathway dampens the efficiency of PTGS, likely by limiting the availability of AGO1. mir168 argonaute RISC component 1 Homo sapiens
3 Moreover, increasing AGO1 levels either by mutating miRNA pathway components or, more specifically, by impairing miR168-directed regulation of AGO1 mRNA leads to increased PTGS efficiency, indicating that the miRNA pathway dampens the efficiency of PTGS, likely by limiting the availability of AGO1. mir168 argonaute RISC component 1 Homo sapiens