Title : Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53.

Pub. Date : 2011 Nov

PMID : 21811093






12 Functional Relationships(s)
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1 Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53. Docosahexaenoic Acids tumor protein p53 Homo sapiens
2 Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53. Docosahexaenoic Acids tumor protein p53 Homo sapiens
3 We also observed that DHA-induced autophagy was accompanied by p53 loss. Docosahexaenoic Acids tumor protein p53 Homo sapiens
4 Inhibition of p53 increased DHA-induced autophagy and prevention of p53 degradation significantly led to the attenuation of DHA-induced autophagy, suggesting that DHA-induced autophagy is mediated by p53. Docosahexaenoic Acids tumor protein p53 Homo sapiens
5 Inhibition of p53 increased DHA-induced autophagy and prevention of p53 degradation significantly led to the attenuation of DHA-induced autophagy, suggesting that DHA-induced autophagy is mediated by p53. Docosahexaenoic Acids tumor protein p53 Homo sapiens
6 Inhibition of p53 increased DHA-induced autophagy and prevention of p53 degradation significantly led to the attenuation of DHA-induced autophagy, suggesting that DHA-induced autophagy is mediated by p53. Docosahexaenoic Acids tumor protein p53 Homo sapiens
7 Inhibition of p53 increased DHA-induced autophagy and prevention of p53 degradation significantly led to the attenuation of DHA-induced autophagy, suggesting that DHA-induced autophagy is mediated by p53. Docosahexaenoic Acids tumor protein p53 Homo sapiens
8 Inhibition of p53 increased DHA-induced autophagy and prevention of p53 degradation significantly led to the attenuation of DHA-induced autophagy, suggesting that DHA-induced autophagy is mediated by p53. Docosahexaenoic Acids tumor protein p53 Homo sapiens
9 Inhibition of p53 increased DHA-induced autophagy and prevention of p53 degradation significantly led to the attenuation of DHA-induced autophagy, suggesting that DHA-induced autophagy is mediated by p53. Docosahexaenoic Acids tumor protein p53 Homo sapiens
10 Inhibition of p53 increased DHA-induced autophagy and prevention of p53 degradation significantly led to the attenuation of DHA-induced autophagy, suggesting that DHA-induced autophagy is mediated by p53. Docosahexaenoic Acids tumor protein p53 Homo sapiens
11 Further experiments showed that the mechanism of DHA-induced autophagy associated with p53 attenuation involved an increase in the active form of AMP-activated protein kinase and a decrease in the activity of mammalian target of rapamycin. Docosahexaenoic Acids tumor protein p53 Homo sapiens
12 Overall, our results demonstrate that autophagy contributes to the cytotoxicity of DHA in cancer cells harboring wild-type p53. Docosahexaenoic Acids tumor protein p53 Homo sapiens