Title : IL-1R-associated kinase-1 mediates protein kinase Cδ-induced IL-1β production in monocytes.

Pub. Date : 2011 Sep 1

PMID : 21804018






3 Functional Relationships(s)
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1 Moreover, PMA-induced IL-1beta production was significantly reduced in the presence of TLR2, TLR4, and CD11b Abs. Tetradecanoylphorbol Acetate interleukin 1 beta Homo sapiens
2 Rottlerin, a PKCdelta-specific inhibitor, significantly reduced PMA-induced IL-1beta production as well as CD11b, TLR2 expression, and IRAK1-JNK activation. Tetradecanoylphorbol Acetate interleukin 1 beta Homo sapiens
3 IRAK1/4 inhibitors, their small interfering RNAs, and JNK inhibitor also attenuated PMA-induced IL-1beta production. Tetradecanoylphorbol Acetate interleukin 1 beta Homo sapiens