Title : Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice.

Pub. Date : 2012 Aug

PMID : 21803451






2 Functional Relationships(s)
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1 APalpha significantly increased survival of bromodeoxyuridine positive (BrdU+) cells and hippocampal-dependent associative learning and memory in 3xTgAD mice in the presence of intraneuronal amyloid beta (Abeta) whereas APalpha was ineffective subsequent to development of extraneuronal Abeta plaques. Bromodeoxyuridine glutamyl aminopeptidase Mus musculus
2 In aged 15-month-old nonTg mice, APalpha significantly increased survival of bromodeoxyuridine-positive cells and hippocampal-dependent associative learning and memory. Bromodeoxyuridine glutamyl aminopeptidase Mus musculus