Title : Oxysterols direct immune cell migration via EBI2.

Pub. Date : 2011 Jul 27

PMID : 21796212






2 Functional Relationships(s)
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1 Functional activation of human EBI2 by 7alpha,25-OHC and closely related oxysterols was verified by monitoring second messenger readouts and saturable, high-affinity radioligand binding. 25-hydroxycholesterol G protein-coupled receptor 183 Homo sapiens
2 Furthermore, we find that 7alpha,25-OHC and closely related oxysterols act as chemoattractants for immune cells expressing EBI2 by directing cell migration in vitro and in vivo. 25-hydroxycholesterol G protein-coupled receptor 183 Homo sapiens