Pub. Date : 2011 Sep 16
PMID : 21795682
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We present here biophysical and biochemical studies that have enabled us to characterize the interaction of metal-substituted, tetrasulfonated phthalocyanines (PcTS) with alpha-synuclein (AS), the major protein component of amyloid-like deposits in Parkinson disease. | Metals | long intergenic non-protein coding RNA 2605 | Homo sapiens |
| 2 | Using NMR and electronic absorption spectroscopies we demonstrated conclusively that the differences in binding capacity and anti-amyloid activity of phthalocyanines on AS are attributed to their relative ability to self-stack through pi-pi interactions, modulated by the nature of the metal ion bound at the molecule. | Metals | long intergenic non-protein coding RNA 2605 | Homo sapiens |