Title : Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport.

Pub. Date : 2012 Apr

PMID : 21794954






2 Functional Relationships(s)
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1 Here, we show that phosphorylation of tau at tyrosine 18, which is a fyn phosphorylation site within PAD, prevents inhibition of anterograde FAT induced by both filamentous tau and 6D tau. Tyrosine FYN proto-oncogene, Src family tyrosine kinase Homo sapiens
2 Moreover, Fyn-mediated phosphorylation of tyrosine 18 is reduced in disease-associated forms of tau (e.g., tau filaments). Tyrosine FYN proto-oncogene, Src family tyrosine kinase Homo sapiens