Title : Δ9-tetrahydrocannabinol suppresses cytotoxic T lymphocyte function independent of CB1 and CB 2, disrupting early activation events.

Pub. Date : 2012 Dec

PMID : 21789506






3 Functional Relationships(s)
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1 Delta(9)-THC increased expression of the activation markers, CD69 in CD8(+) cells and CD25 in CD4(+) cells in a concentration-dependent manner in cells derived from WT and CB(1) (-/-)CB(2) (-/-) mice. Dronabinol CD69 antigen Mus musculus
2 Furthermore, Delta(9)-THC synergized with the calcium ionophore, ionomycin, to increase CD69 expression on both CD4(+) and CD8(+) cells. Dronabinol CD69 antigen Mus musculus
3 In addition, without stimulation, Delta(9)-THC increased CD69 expression in CD8(+) cells from CB(1) (-/-)CB(2) (-/-) and WT mice. Dronabinol CD69 antigen Mus musculus