Pub. Date : 2011 Jul 19
PMID : 21775285
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Akt is activated during growth factor stimulation through a process that requires binding of Akt to phosphatidylinositol 3,4,5-trisphosphate (PIP(3)), which promotes membrane localization and phosphorylation of Akt by the upstream kinase PDK1 (phosphoinositide-dependent protein kinase 1). | pip(3) | thymoma viral proto-oncogene 1 | Mus musculus |
2 | Akt is activated during growth factor stimulation through a process that requires binding of Akt to phosphatidylinositol 3,4,5-trisphosphate (PIP(3)), which promotes membrane localization and phosphorylation of Akt by the upstream kinase PDK1 (phosphoinositide-dependent protein kinase 1). | pip(3) | thymoma viral proto-oncogene 1 | Mus musculus |
3 | Akt is activated during growth factor stimulation through a process that requires binding of Akt to phosphatidylinositol 3,4,5-trisphosphate (PIP(3)), which promotes membrane localization and phosphorylation of Akt by the upstream kinase PDK1 (phosphoinositide-dependent protein kinase 1). | pip(3) | thymoma viral proto-oncogene 1 | Mus musculus |
4 | We show that Akt and PDK1 are acetylated at lysine residues in their pleckstrin homology domains, which mediate PIP(3) binding. | pip(3) | thymoma viral proto-oncogene 1 | Mus musculus |
5 | Acetylation blocked binding of Akt and PDK1 to PIP(3), thereby preventing membrane localization and phosphorylation of Akt. | pip(3) | thymoma viral proto-oncogene 1 | Mus musculus |
6 | Acetylation blocked binding of Akt and PDK1 to PIP(3), thereby preventing membrane localization and phosphorylation of Akt. | pip(3) | thymoma viral proto-oncogene 1 | Mus musculus |
7 | Deacetylation by SIRT1 enhanced binding of Akt and PDK1 to PIP(3) and promoted their activation. | pip(3) | thymoma viral proto-oncogene 1 | Mus musculus |