Title : Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.

Pub. Date : 2011 Oct 15

PMID : 21768216






1 Functional Relationships(s)
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1 Here, two of these inhibitors, GW5074 and sorafenib, are shown to protect against G2019S LRRK2-induced neurodegeneration in vivo in Caenorhabditis elegans and in Drosophila. 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone Leucine-rich repeat kinase Drosophila melanogaster