Title : A new pathway of CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase.

Pub. Date : 2011 Sep 2

PMID : 21757751






4 Functional Relationships(s)
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1 After CD5 ligation, phosphorylation of the negative regulatory tyrosine (Tyr(531)) of Fyn increases, and this correlates with a substantial reduction in the kinase activity of Fyn and a profound inhibition of ZAP-70 activation. Tyrosine FYN proto-oncogene, Src family tyrosine kinase Homo sapiens
2 After CD5 ligation, phosphorylation of the negative regulatory tyrosine (Tyr(531)) of Fyn increases, and this correlates with a substantial reduction in the kinase activity of Fyn and a profound inhibition of ZAP-70 activation. Tyrosine FYN proto-oncogene, Src family tyrosine kinase Homo sapiens
3 After CD5 ligation, phosphorylation of the negative regulatory tyrosine (Tyr(531)) of Fyn increases, and this correlates with a substantial reduction in the kinase activity of Fyn and a profound inhibition of ZAP-70 activation. Tyrosine FYN proto-oncogene, Src family tyrosine kinase Homo sapiens
4 After CD5 ligation, phosphorylation of the negative regulatory tyrosine (Tyr(531)) of Fyn increases, and this correlates with a substantial reduction in the kinase activity of Fyn and a profound inhibition of ZAP-70 activation. Tyrosine FYN proto-oncogene, Src family tyrosine kinase Homo sapiens