Title : Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft.

Pub. Date : 2011 Aug 23

PMID : 21755988






1 Functional Relationships(s)
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1 This supports a model in which Hsp70 binding to apo-nNOS stabilizes an open state of the heme/substrate binding cleft to facilitate thioredoxin access to the active site cysteine that coordinates with heme iron, permitting heme binding and dimerization to the active enzyme. Iron heat shock protein family A (Hsp70) member 4 Homo sapiens