Title : HDAC inhibition promotes cardiogenesis and the survival of embryonic stem cells through proteasome-dependent pathway.

Pub. Date : 2011 Nov

PMID : 21751234






2 Functional Relationships(s)
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1 Using the well-established mouse ESC culture, we demonstrated that HDAC inhibitors, both trichostatin A (TSA,50 nmol/L) and sodium butyrate (NaB, 200 micromol/L) that causes the pronounced reduction of HDAC4 activity, decreased cell death and increased viability of ESCs in response to oxidant stress. trichostatin A histone deacetylase 4 Mus musculus
2 Using the well-established mouse ESC culture, we demonstrated that HDAC inhibitors, both trichostatin A (TSA,50 nmol/L) and sodium butyrate (NaB, 200 micromol/L) that causes the pronounced reduction of HDAC4 activity, decreased cell death and increased viability of ESCs in response to oxidant stress. trichostatin A histone deacetylase 4 Mus musculus