Title : Olanzapine metabolism and the significance of UGT1A448V and UGT2B1067Y variants.

Pub. Date : 2011 Sep

PMID : 21750471






1 Functional Relationships(s)
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1 There was a 1.9-fold (P<0.003) decrease in the formation of both isomers of the olanzapine-10-N-glucuronide, a 2.7-fold (P<0.0001) decrease in olanzapine-4"-N-glucuronide formation, and a 2.1-fold (P=0.0002) decrease in the overall olanzapine glucuronide formation in HLM with at least one UGT2B10*2 allele. Glucuronides UDP glucuronosyltransferase family 2 member B10 Homo sapiens