Title : PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity.

Pub. Date : 2011 Nov

PMID : 21750219






1 Functional Relationships(s)
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1 PF-04691502 is an ATP-competitive PI3K/mTOR dual inhibitor, which potently inhibited recombinant class I PI3K and mTOR in biochemical assays and suppressed transformation of avian fibroblasts mediated by wild-type PI3K gamma, delta, or mutant PI3Kalpha. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Homo sapiens