Title : Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation.

Pub. Date : 2011 Oct

PMID : 21742779






1 Functional Relationships(s)
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Protein Name
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1 Upon exposure to H(2)O(2), Akt was intensely phosphorylated in the first 30 min, concurrently with mammalian target of rapamycin inactivation and autophagy, and it was dephosphorylated at 2 h, when > 50% of the cells were dead. Water AKT serine/threonine kinase 1 Homo sapiens